Anti-Inflammatory Effects of Dietary Polyphenols through Inhibitory Activity against Metalloproteinases

Matrix metalloproteinases (MMPs) are zinc-dependent that play important roles in a variety of diseases, including cancer, cardiovascular disease, diabetes, obesity, and brain diseases. Dietary polyphenols thought to have beneficial effects on these diseases characterized by inflammation. Clinical studies demonstrated MMPs most cases upregulated various inflammatory osteoarthritis, rheumatoid arthritis, bowel Alzheimer’s disease. Studies using patient-derived human samples, animal studies, cellular experiments suggested may be against suppressing MMP gene expression enzyme activity. One mechanism which exert their activity is the downregulation reactive oxygen species promote expression. Another direct binding inhibition Molecular docking analyses provided structural basis for interaction between will help explore new polyphenol-based drugs with anti-inflammatory properties.